Azizoglu DB, Perez K, Zheng SL, Rahman S, Rim EY, Anbarchian T, Fish M, Loh KM, Red-Horse K, Nusse R. Liver size is predetermined in the neonate by adding lobules at the periphery. In Revision, Nature. Submitted: 2023 Nov; 34 pages. bioRxiv 2023.10.12.562109

Synopsis: We find that the size of the adult mouse liver is predetermined in a neonatal period by the angiogenic capacity of a newly-identified endothelial progenitor pool, rather than by the proliferation rate of hepatocytes.

Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O. Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74.

Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, et al. (2019) LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol 17(7): e3000382.

Daniel E, Azizoglu DB, Ryan A, Walji T, Chaney C, Sutton G, Carroll TJ, Marciano DK, Cleaver O. Spatiotemporal heterogeneity and patterning of developing renal blood vessels. Angiogenesis. 2018 Aug;21(3):617-634.

Azizoglu DB, Braitsch C, Marciano DK, Cleaver O. Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. Genes Dev. 2017 Dec 1;31(23-24):2376-2390. (featured on journal cover)

Synopsis: We find that two cytoskeleton-linked molecules, Afadin and RhoA, support a 3-dimensional mesh of tubes in the embryonic pancreas that in turn serves as a niche for pancreatic progenitors and controls the final endocrine mass in this critical metabolic organ.

Azizoglu DB, Chong DC, Villasenor A, Magenheim J, Barry DM, Lee S, Marty-Santos L, Fu S, Dor Y, Cleaver O. Vascular development in the vertebrate pancreas. Dev Biol. 2016 Dec 1;420(1):67-78.

Synopsis: We provide a step-by-step anatomical and molecular characterization of how the pancreas is vascularized in the mouse embryo.

Barry DM, Koo YS, Norden PR, Wylie LA, Xu K, Wichaidit C, Azizoglu DB, Zheng Y, Cobb MH, Davis G, Cleaver O. Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Non-Muscle Myosin II. Circ Res. 2016 Sep 16;119(7):810-26.

Azizoglu DB, Cleaver O. Blood vessel crosstalk during organogenesis-focus on pancreas and endothelial cells. Wiley Interdiscip Rev Dev Biol. 2016 Sep;5(5):598-617. (review article, featured on journal cover).