Vascularization of neonatal liver lobules presages adult liver size

Azizoglu DB, Perez K, Zheng SL, Rahman S, Rim EY, Anbarchian T, Fish M, Loh KM, Red-Horse K, Nusse R. Vascularization of neonatal liver lobules presages adult liver size. Nat Commun. 2025 Nov 13;16(1):9989. 

Synopsis: We find that the size of the adult mouse liver is predetermined in a neonatal period by the angiogenic capacity of a newly-identified endothelial progenitor pool, rather than by the proliferation rate of hepatocytes.